Peptide RX

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proof receipt / fold

ESR1 WT

Structure prediction with public confidence context.

grade B status complete receipt f397c88d356a proof 67%

what this node claims

ESR1 WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 ESR1 WT fold / grade B / 54% 3 debt
  2. 02 AlphaFold metrics / ESR1 alphafold metric / grade B / 70% 1 debt
  3. 03 Initial digest — ESR1 finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 ESR1 target / grade B / 70% 1 debt

evidence / risk instrument

47%
thin proof
structure evidence gates risk export lineage 47
visible debt pressure 50%
66%structureusable
pLDDT 66.43
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
low
confidence pct
66.43
coverage available
false
gene
ESR1
has structure
true
pae available
false
plddt avg
66.43
sequence length
0
variant
WT

AlphaFold metrics visual

Low-confidence regions present

66.4

595 residues / min 26.55 / max 98.62 / source alphafold db

PAE matrix for linked target
Very high 43.5% 259 residues / >=90
Confident 6.9% 41 residues / 70-89
Low 3.2% 19 residues / 50-69
Very low 46.4% 276 residues / <50

weak structural context; downstream claims should be conservative

Near-complete coverage / observed 595 of 595 residues.

  • residues 1-180 / mean 36.06
  • residues 254-304 / mean 40.24
  • residues 549-595 / mean 38.21
  • residues 457-472 / mean 53.24
proof debt register

Visible limits, not hidden cleanup.

50%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
low low-confidence AlphaFold regions likely attach pLDDT series, PAE matrix, or coverage evidence
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
low-confidence AlphaFold regions likely low visible watch attach pLDDT series, PAE matrix, or coverage evidence
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:a148aaff-1bd8-4d17-8c18-6993de5af7ed -> fold:4ceebcc0-36e6-45e5-a7bb-120c5061b214 folds_to / B / 0.664

what it supports

measured by AlphaFold confidence context fold:4ceebcc0-36e6-45e5-a7bb-120c5061b214 -> alphafold_metric:4ceebcc0-36e6-45e5-a7bb-120c5061b214 measured_by / B / 0.664
evidence finding attached fold:4ceebcc0-36e6-45e5-a7bb-120c5061b214 -> finding:ad96fe68-f511-41aa-90c9-855c094d24dc supports / C / 0.6
timeline records state change fold:4ceebcc0-36e6-45e5-a7bb-120c5061b214 -> timeline_event:35 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.