Peptide RX

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proof receipt / alphafold metric

AlphaFold metrics / ESR1

Model-quality receipt for the fold. It is not biological validation.

grade B status metric-context receipt f2b52d3519b1 proof 33%

what this node claims

AlphaFold metrics / ESR1

Model-quality receipt for the fold. It is not biological validation.

evidence / risk instrument

50%
thin proof
structure evidence gates risk export lineage 50
low debt pressure 24%
66%structureusable
pLDDT 66.43
78%evidenceusable
grade B
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
33%lineagedebt
incomplete spine

proof completeness

33% missing target, candidate, finding, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
low
confidence pct
66.43
coverage context
missing or not linked
interpretation
weak structural context; downstream claims should be conservative
pae context
missing or not linked
plddt avg
66.43
sequence length
0

AlphaFold metrics visual

Low-confidence regions present

66.4

595 residues / min 26.55 / max 98.62 / source alphafold db

PAE matrix for linked target
Very high 43.5% 259 residues / >=90
Confident 6.9% 41 residues / 70-89
Low 3.2% 19 residues / 50-69
Very low 46.4% 276 residues / <50

weak structural context; downstream claims should be conservative

Near-complete coverage / observed 595 of 595 residues.

  • residues 1-180 / mean 36.06
  • residues 254-304 / mean 40.24
  • residues 549-595 / mean 38.21
  • residues 457-472 / mean 53.24
proof debt register

Visible limits, not hidden cleanup.

24%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
low computational-only status add independent evidence, challenge result, or witness review before strengthening
low low-confidence AlphaFold regions likely attach pLDDT series, PAE matrix, or coverage evidence
medium no candidate yet leave visible until a stronger public receipt resolves it

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
low-confidence AlphaFold regions likely low visible watch attach pLDDT series, PAE matrix, or coverage evidence
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it

what supports it

measured by AlphaFold confidence context fold:4ceebcc0-36e6-45e5-a7bb-120c5061b214 -> alphafold_metric:4ceebcc0-36e6-45e5-a7bb-120c5061b214 measured_by / B / 0.664

what it supports

No downstream proof edge yet.

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.