MC4R

Melanocortin-4 receptor / UniProt P32245

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 80.14 Confident backbone model

Residues 332 per-residue parsed

Coverage 100.0% 332/332 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

332 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

332 residues / mean 80.14 / min 27.73 / max 98.5

Very high 48.8% 162 residues / >=90

Confident 28.0% 93 residues / 70-89

Low 8.7% 29 residues / 50-69

Very low 14.5% 48 residues / <50

Coverage

Near-complete coverage: 332 observed of 332 residues.

Low-confidence intervals

res 1-41 / mean 38.38 res 319-332 / mean 48.84 res 232-245 / mean 59.02 res 107-114 / mean 64.9

UniProt P32245 / open in AlphaFold DB

04 / Target context

Biological lane

metabolic

Family

GPCR_class_A

Pocket modes

ortho, allo

Indication tags

obesity, appetite, sexual_function

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	MC4R
Length	332 aa
pLDDT mean	80.14
Confidence	80.14%
pLDDT source	alphafold db
Model state	Confident backbone model
Status	complete
Lane	metabolic

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — MC4R

AlphaFold v6 prediction landed for **MC4R** (Melanocortin-4 receptor). UniProt accession: `P32245`. Lane: `metabolic`. Mean per-residue pLDDT: **80.14**. Selec...