Peptide RX

back to claim graph

proof receipt / fold

MC4R WT

Structure prediction with public confidence context.

grade B status complete receipt 52d788cb7af4 proof 67%

what this node claims

MC4R WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 MC4R WT fold / grade B / 64% 2 debt
  2. 02 AlphaFold metrics / MC4R alphafold metric / grade B / 72% 1 debt
  3. 03 Initial digest — MC4R finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 MC4R target / grade B / 70% 1 debt

evidence / risk instrument

50%
thin proof
structure evidence gates risk export lineage 50
visible debt pressure 47%
80%structurestrong
pLDDT 80.14
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
80.14
coverage available
false
gene
MC4R
has structure
true
pae available
false
plddt avg
80.14
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

80.1

332 residues / min 27.73 / max 98.5 / source alphafold db

PAE matrix for linked target
Very high 48.8% 162 residues / >=90
Confident 28.0% 93 residues / 70-89
Low 8.7% 29 residues / 50-69
Very low 14.5% 48 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 332 of 332 residues.

  • residues 1-41 / mean 38.38
  • residues 319-332 / mean 48.84
  • residues 232-245 / mean 59.02
  • residues 107-114 / mean 64.9
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:3a141813-fe18-45ca-949c-73df4eb9ab47 -> fold:d388fa59-d070-4ae5-8458-2a6ea03a1551 folds_to / B / 0.801

what it supports

measured by AlphaFold confidence context fold:d388fa59-d070-4ae5-8458-2a6ea03a1551 -> alphafold_metric:d388fa59-d070-4ae5-8458-2a6ea03a1551 measured_by / B / 0.801
evidence finding attached fold:d388fa59-d070-4ae5-8458-2a6ea03a1551 -> finding:65226ee0-ee81-444a-89dc-2ba55f484062 supports / C / 0.6
timeline records state change fold:d388fa59-d070-4ae5-8458-2a6ea03a1551 -> timeline_event:6 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.