Initial digest — MC4R receipt

what this node claims

Initial digest — MC4R

AlphaFold v6 prediction landed for **MC4R** (Melanocortin-4 receptor). UniProt accession: `P32245`. Lane: `metabolic`. Mean per-residue pLDDT: **80.14**. Selectivity vs MC1R/MC3R is the design challenge.

Open source surface

vertical proof spine

evidence / risk instrument

39%

thin proof

low debt pressure 29%

28%structuredebt

pLDDT pending

55%evidencethin

grade C

0%gatesdebt

0/5 gates

100%riskstrong

0 hard flags

22%exportdebt

no export

33%lineagedebt

incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export

01 target
02 fold
03 alphafold metric
04 candidate
05 finding
06 export

Metrics and receipt inputs

confidence: 0.6
evidence refs: 1

AlphaFold metrics visual

Confident backbone model

80.1

332 residues / min 27.73 / max 98.5 / source alphafold db

Very high 48.8% 162 residues / >=90

Confident 28.0% 93 residues / 70-89

Low 8.7% 29 residues / 50-69

Very low 14.5% 48 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 332 of 332 residues.

residues 1-41 / mean 38.38
residues 319-332 / mean 48.84
residues 232-245 / mean 59.02
residues 107-114 / mean 64.9

proof debt register

Visible limits, not hidden cleanup.

29%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence

low computational-only status add independent evidence, challenge result, or witness review before strengthening

medium no candidate yet leave visible until a stronger public receipt resolves it

Initial digest — MC4R