what this node claims
PRX-GHSR-001
Public-safe candidate workup with gates, grade, and redacted sequence.
vertical proof spine
- 01 GHSR1a target / grade B / 70% 1 debt
- 02 GHSR WT fold / grade B / 74% 1 debt
- 03 AlphaFold metrics / GHSR alphafold metric / grade B / 74% 1 debt
- 04 PRX-GHSR-001 candidate / grade D / 36% 3 debt
- 05 Initial digest — GHSR1a finding / grade C / 47% 1 debt
- 06 Research pack / PRX-GHSR-001 export / grade D / 10% 3 debt
evidence / risk instrument
69%
visible debt pressure
60%
82%structurestrong
pLDDT 81.6
55%evidencethin
grade C
60%gatesusable
3/5 gates
100%riskstrong
0 hard flags
92%exportstrong
surface linked
100%lineagestrong
complete spine
proof completeness
100% complete spine- 01 target
- 02 fold
- 03 alphafold metric
- 04 candidate
- 05 finding
- 06 export
Metrics and receipt inputs
- affinity kd nm
- pending
- binding tier
- very_strong
- drug likeness score
- pending
- gate passed
- 3
- gate status
-
{"gate_0": true, "gate_1": true, "gate_2": true, "gate_3": true, "gate_4": false, "gate_5": false} - half life class
- medium
- pocket mode
- ortho
- pop shield tier
- green
- predicted affinity kcal mol
- -11.3
- regulatory status
- class_2_research_only
- risk flags
-
{"aggregation_flag": false, "ames_flag": false, "cyp_flag": false, "fto_flag": false, "herg_flag": false, "immunogenicity_score": null, "wada_flag": false} - sequence redacted
- true
- structure confidence
- 0.89
- target region
- ortho
AlphaFold metrics visual
Confident backbone model
366 residues / min 27.77 / max 98.75 / source alphafold db
Very high
50.8%
186 residues / >=90
Confident
27.3%
100 residues / 70-89
Low
11.5%
42 residues / 50-69
Very low
10.4%
38 residues / <50
usable fold context with explicit model-confidence limits
Near-complete coverage / observed 366 of 366 residues.
- residues 1-36 / mean 35.02
- residues 341-366 / mean 56.57
- residues 284-294 / mean 65.33
- residues 246-251 / mean 60.33
proof debt register
60%
Visible limits, not hidden cleanup.
Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.