Peptide RX

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proof receipt / target

GHSR1a

Growth hormone secretagogue receptor 1a (ghrelin receptor)

grade B status metabolic receipt 54e992d4b313 proof 50%

what this node claims

GHSR1a

Growth hormone secretagogue receptor 1a (ghrelin receptor)

Open source surface

vertical proof spine

  1. 01 GHSR1a target / grade B / 70% 1 debt
  2. 02 Effect design run idea / grade C / 55%
  3. 03 PRX-GHSR-001 candidate / grade D / 36% 3 debt
  4. 04 PRX-GHSR-002 candidate / grade D / 36% 3 debt
  5. 05 GHSR WT fold / grade B / 74% 1 debt

evidence / risk instrument

43%
thin proof
structure evidence gates risk export lineage 43
visible debt pressure 58%
28%structuredebt
pLDDT pending
34%evidencedebt
grade D
60%gatesusable
3/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
50%lineagethin
incomplete spine

proof completeness

50% missing alphafold_metric, finding, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

binding partners
    context annotations
    0
    family
    GPCR_class_A
    functional sites
      gene symbol
      GHSR
      go terms
        uniprot
        Q92847

        AlphaFold metrics visual

        Confident backbone model

        81.6

        366 residues / min 27.77 / max 98.75 / source alphafold db

        PAE matrix for linked target
        Very high 50.8% 186 residues / >=90
        Confident 27.3% 100 residues / 70-89
        Low 11.5% 42 residues / 50-69
        Very low 10.4% 38 residues / <50

        usable fold context with explicit model-confidence limits

        Near-complete coverage / observed 366 of 366 residues.

        • residues 1-36 / mean 35.02
        • residues 341-366 / mean 56.57
        • residues 284-294 / mean 65.33
        • residues 246-251 / mean 60.33
        proof debt register

        Visible limits, not hidden cleanup.

        58%

        Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

        medium missing functional-site annotations link target annotation, GO term, or binding-site context
        low computational-only status add independent evidence, challenge result, or witness review before strengthening
        high low evidence grade attach graded finding with source-linked evidence
        low sequence redacted keep sequence redacted publicly; expose only through authorized records
        low computational-only status add independent evidence, challenge result, or witness review before strengthening
        high low evidence grade attach graded finding with source-linked evidence

        weakness and challenge edges

        What would stop this from becoming stronger.

        debt severity export claim strength next proof needed
        missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context
        computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
        low evidence grade high blocks weakens attach graded finding with source-linked evidence
        sequence redacted low visible watch keep sequence redacted publicly; expose only through authorized records
        computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
        low evidence grade high blocks weakens attach graded finding with source-linked evidence
        sequence redacted low visible watch keep sequence redacted publicly; expose only through authorized records
        computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening

        what supports it

        effect run matched target idea:effect-run:5b6e0a6a-49f2-46e5-a721-92bd1daa7fcd -> target:eec1bc4d-2823-4f2e-978f-afd3ccc93a4c targets / C / 0.52

        what it supports

        target drives candidate design target:eec1bc4d-2823-4f2e-978f-afd3ccc93a4c -> candidate:PRX-GHSR-001 designs / D / 0.64
        target drives candidate design target:eec1bc4d-2823-4f2e-978f-afd3ccc93a4c -> candidate:PRX-GHSR-002 designs / D / 0.64
        target has structure prediction target:eec1bc4d-2823-4f2e-978f-afd3ccc93a4c -> fold:e3519416-ff73-4f3e-ad8a-83273dc604c2 folds_to / B / 0.816

        Research-use boundary

        This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.