Peptide RX

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proof receipt / candidate

PRX-GHSR-002

Public-safe candidate workup with gates, grade, and redacted sequence.

grade D status gates 3/5 receipt 3a858f690d99 proof 100%

what this node claims

PRX-GHSR-002

Public-safe candidate workup with gates, grade, and redacted sequence.

Open source surface Research pack

vertical proof spine

  1. 01 GHSR1a target / grade B / 70% 1 debt
  2. 02 GHSR WT fold / grade B / 74% 1 debt
  3. 03 AlphaFold metrics / GHSR alphafold metric / grade B / 74% 1 debt
  4. 04 PRX-GHSR-002 candidate / grade D / 36% 3 debt
  5. 05 Initial digest — GHSR1a finding / grade C / 47% 1 debt
  6. 06 Research pack / PRX-GHSR-002 export / grade D / 10% 3 debt

evidence / risk instrument

69%
usable with debt
structure evidence gates risk export lineage 69
visible debt pressure 60%
82%structurestrong
pLDDT 81.6
55%evidencethin
grade C
60%gatesusable
3/5 gates
100%riskstrong
0 hard flags
92%exportstrong
surface linked
100%lineagestrong
complete spine

proof completeness

100% complete spine
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

affinity kd nm
pending
binding tier
very_strong
drug likeness score
pending
gate passed
3
gate status
{"gate_0": true, "gate_1": true, "gate_2": true, "gate_3": true, "gate_4": false, "gate_5": false}
half life class
medium
pocket mode
ortho
pop shield tier
green
predicted affinity kcal mol
-7.9
regulatory status
class_2_research_only
risk flags
{"aggregation_flag": false, "ames_flag": false, "cyp_flag": false, "fto_flag": false, "herg_flag": false, "immunogenicity_score": null, "wada_flag": false}
sequence redacted
true
structure confidence
0.96
target region
ortho

AlphaFold metrics visual

Confident backbone model

81.6

366 residues / min 27.77 / max 98.75 / source alphafold db

PAE matrix for linked target
Very high 50.8% 186 residues / >=90
Confident 27.3% 100 residues / 70-89
Low 11.5% 42 residues / 50-69
Very low 10.4% 38 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 366 of 366 residues.

  • residues 1-36 / mean 35.02
  • residues 341-366 / mean 56.57
  • residues 284-294 / mean 65.33
  • residues 246-251 / mean 60.33
proof debt register

Visible limits, not hidden cleanup.

60%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
high low evidence grade attach graded finding with source-linked evidence
low sequence redacted keep sequence redacted publicly; expose only through authorized records
low not clinical validation keep the research-use boundary visible; do not promote as clinical
low research-use export only keep the research-use boundary visible; do not promote as clinical
low sequence redacted keep sequence redacted publicly; expose only through authorized records

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
low evidence grade high blocks weakens attach graded finding with source-linked evidence
sequence redacted low visible watch keep sequence redacted publicly; expose only through authorized records
not clinical validation low visible watch keep the research-use boundary visible; do not promote as clinical
research-use export only low visible watch keep the research-use boundary visible; do not promote as clinical
sequence redacted low visible watch keep sequence redacted publicly; expose only through authorized records
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context
no direct evidence finding yet high blocks weakens attach graded finding with source-linked evidence

what supports it

target fold context projected to candidate fold:e3519416-ff73-4f3e-ad8a-83273dc604c2 -> candidate:PRX-GHSR-002 designs / D / 0.64
effect run proposed candidate idea:effect-run:5b6e0a6a-49f2-46e5-a721-92bd1daa7fcd -> candidate:PRX-GHSR-002 proposes / C / 0.58
target drives candidate design target:eec1bc4d-2823-4f2e-978f-afd3ccc93a4c -> candidate:PRX-GHSR-002 designs / D / 0.64

what it supports

candidate has public research-pack surface candidate:PRX-GHSR-002 -> export:candidate:PRX-GHSR-002 exports / D / 0.72

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.