Peptide RX

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proof receipt / fold

GHSR WT

Structure prediction with public confidence context.

grade B status complete receipt 7400a5385cdd proof 100%

what this node claims

GHSR WT

Structure prediction with public confidence context.

Open source surface Research pack

vertical proof spine

  1. 01 GHSR1a target / grade B / 70% 1 debt
  2. 02 GHSR WT fold / grade B / 74% 1 debt
  3. 03 AlphaFold metrics / GHSR alphafold metric / grade B / 74% 1 debt
  4. 04 PRX-GHSR-001 candidate / grade D / 36% 3 debt
  5. 05 Initial digest — GHSR1a finding / grade C / 47% 1 debt
  6. 06 Research pack / PRX-GHSR-001 export / grade D / 10% 3 debt

evidence / risk instrument

65%
debt-heavy
structure evidence gates risk export lineage 65
high debt pressure 83%
82%structurestrong
pLDDT 81.6
55%evidencethin
grade C
60%gatesusable
3/5 gates
100%riskstrong
0 hard flags
92%exportstrong
surface linked
100%lineagestrong
complete spine

proof completeness

100% complete spine
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
81.6
coverage available
false
gene
GHSR
has structure
true
pae available
false
plddt avg
81.6
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

81.6

366 residues / min 27.77 / max 98.75 / source alphafold db

PAE matrix for linked target
Very high 50.8% 186 residues / >=90
Confident 27.3% 100 residues / 70-89
Low 11.5% 42 residues / 50-69
Very low 10.4% 38 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 366 of 366 residues.

  • residues 1-36 / mean 35.02
  • residues 341-366 / mean 56.57
  • residues 284-294 / mean 65.33
  • residues 246-251 / mean 60.33
proof debt register

Visible limits, not hidden cleanup.

83%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
low computational-only status add independent evidence, challenge result, or witness review before strengthening
high low evidence grade attach graded finding with source-linked evidence
low sequence redacted keep sequence redacted publicly; expose only through authorized records
low computational-only status add independent evidence, challenge result, or witness review before strengthening

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
low evidence grade high blocks weakens attach graded finding with source-linked evidence
sequence redacted low visible watch keep sequence redacted publicly; expose only through authorized records
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
low evidence grade high blocks weakens attach graded finding with source-linked evidence
sequence redacted low visible watch keep sequence redacted publicly; expose only through authorized records
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:eec1bc4d-2823-4f2e-978f-afd3ccc93a4c -> fold:e3519416-ff73-4f3e-ad8a-83273dc604c2 folds_to / B / 0.816

what it supports

measured by AlphaFold confidence context fold:e3519416-ff73-4f3e-ad8a-83273dc604c2 -> alphafold_metric:e3519416-ff73-4f3e-ad8a-83273dc604c2 measured_by / B / 0.816
target fold context projected to candidate fold:e3519416-ff73-4f3e-ad8a-83273dc604c2 -> candidate:PRX-GHSR-001 designs / D / 0.64
target fold context projected to candidate fold:e3519416-ff73-4f3e-ad8a-83273dc604c2 -> candidate:PRX-GHSR-002 designs / D / 0.64
evidence finding attached fold:e3519416-ff73-4f3e-ad8a-83273dc604c2 -> finding:45e3bb34-6b42-4b1f-a285-e1224ff92d0d supports / C / 0.6
timeline records state change fold:e3519416-ff73-4f3e-ad8a-83273dc604c2 -> timeline_event:4 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.