Initial digest — Klotho-FGF23 receipt

what this node claims

Initial digest — Klotho-FGF23

AlphaFold v6 prediction landed for **Klotho-FGF23** (α-Klotho / FGF23 axis). UniProt accession: `Q9UEF7`. Lane: `longevity`. Mean per-residue pLDDT: **89.09**. Mimetics — peptide fragments shown to extend healthspan i...

Open source surface

vertical proof spine

evidence / risk instrument

39%

thin proof

low debt pressure 29%

28%structuredebt

pLDDT pending

55%evidencethin

grade C

0%gatesdebt

0/5 gates

100%riskstrong

0 hard flags

22%exportdebt

no export

33%lineagedebt

incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export

01 target
02 fold
03 alphafold metric
04 candidate
05 finding
06 export

Metrics and receipt inputs

confidence: 0.6
evidence refs: 1

AlphaFold metrics visual

Confident backbone model

89.1

1012 residues / min 28.19 / max 98.81 / source alphafold db

Very high 72.9% 738 residues / >=90

Confident 17.5% 177 residues / 70-89

Low 4.1% 41 residues / 50-69

Very low 5.5% 56 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 1012 of 1012 residues.

residues 1-33 / mean 37.0
residues 97-119 / mean 41.65
residues 957-979 / mean 56.7
residues 1007-1012 / mean 55.1

proof debt register

Visible limits, not hidden cleanup.

29%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence

low computational-only status add independent evidence, challenge result, or witness review before strengthening

medium no candidate yet leave visible until a stronger public receipt resolves it

Initial digest — Klotho-FGF23