Peptide RX

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proof receipt / fold

KL WT

Structure prediction with public confidence context.

grade B status complete receipt 27518b8623e0 proof 67%

what this node claims

KL WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 KL WT fold / grade B / 73% 2 debt
  2. 02 AlphaFold metrics / KL alphafold metric / grade B / 81% 1 debt
  3. 03 Initial digest — Klotho-FGF23 finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 Klotho-FGF23 target / grade B / 70% 1 debt

evidence / risk instrument

51%
thin proof
structure evidence gates risk export lineage 51
visible debt pressure 47%
89%structurestrong
pLDDT 89.09
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
89.09
coverage available
false
gene
KL
has structure
true
pae available
false
plddt avg
89.09
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

89.1

1012 residues / min 28.19 / max 98.81 / source alphafold db

PAE matrix for linked target
Very high 72.9% 738 residues / >=90
Confident 17.5% 177 residues / 70-89
Low 4.1% 41 residues / 50-69
Very low 5.5% 56 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 1012 of 1012 residues.

  • residues 1-33 / mean 37.0
  • residues 97-119 / mean 41.65
  • residues 957-979 / mean 56.7
  • residues 1007-1012 / mean 55.1
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:b54b3084-fa26-423d-b8ed-1dc4d20b39f1 -> fold:eeefd326-126b-483a-8a74-9bf047523bf7 folds_to / B / 0.891

what it supports

measured by AlphaFold confidence context fold:eeefd326-126b-483a-8a74-9bf047523bf7 -> alphafold_metric:eeefd326-126b-483a-8a74-9bf047523bf7 measured_by / B / 0.891
evidence finding attached fold:eeefd326-126b-483a-8a74-9bf047523bf7 -> finding:ab0c94f3-d339-458f-a990-990031fbc616 supports / C / 0.6
timeline records state change fold:eeefd326-126b-483a-8a74-9bf047523bf7 -> timeline_event:9 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.